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Education · listen to your body

Lyme Disease & Symptoms

Lyme disease isn't always straightforward. Understanding the signs and symptoms is an important place to start.

Notice the pattern, not just one moment.

Lyme Disease symptoms can appear at different times and may overlap with other illnesses. A rash does not always appear, and not every rash has the same shape. When symptoms continue or change, a healthcare professional can help evaluate possible causes and recommend the next step.

Early signs

Early signs (days to weeks after a tick bite):

  • Erythema migrans, the expanding 'bull's-eye' rash, in about 70-80 percent of cases
  • Additional rashes on other parts of the body once the infection has spread
  • Fever and chills, flu-like illness
  • Fatigue
  • Headache and neck stiffness
  • Muscle and joint aches
  • Swollen lymph nodes
  • Facial palsy (drooping on one or both sides of the face)
  • Heart palpitations or an irregular heartbeat (Lyme carditis)

Source: CDC, Signs and Symptoms of Lyme Disease. Educational information only.

Later signs

Later signs and symptoms of untreated Lyme disease may include:

  • Severe headaches and neck stiffness
  • Additional rashes on other areas of the body
  • Facial palsy (loss of muscle tone or drooping on one or both sides of the face)
  • Arthritis with severe joint pain and swelling, particularly the knees
  • Heart palpitations or an irregular heartbeat, dizziness or shortness of breath
  • Nerve pain; shooting pains, numbness or tingling in the hands or feet

Some people have prolonged symptoms after recommended treatment for Lyme disease. CDC calls this Post-Treatment Lyme Disease Syndrome (PTLDS). Examples may include fatigue, body aches and difficulty thinking. This page is general education and is not a diagnosis. For personal medical advice, contact a licensed clinician.

Source: CDC, Signs and Symptoms of Untreated Lyme Disease; CDC, Chronic Symptoms and Lyme Disease.

What to do next

What to do next:

  • Document symptoms and when they began
  • Photograph rashes or skin changes
  • Note any known or possible tick exposure
  • Keep track of symptoms as they change
  • Share your history and concerns with a healthcare provider
  • Seek urgent care for severe or rapidly changing symptoms

Find the next useful page.

Use provider-directory placeholders, authored explainers, and published sources to build a more informed question list.

Sources & context

Read along with us.

Reviewed August 2026

  1. 01
    About Lyme Disease — CDC

    Explains how Lyme disease spreads, common symptoms, testing, prevention, and standard medical care.

  2. 02
    Signs and Symptoms of Lyme Disease — CDC

    Summarizes symptoms that may occur at different stages and why medical evaluation matters.

  3. 03
    AAN/ACR/IDSA 2020 Lyme Disease Guidelines

    Provides evidence-based clinical guidance for prevention, diagnosis, and treatment decisions.

  4. 04
    Dietary and Herbal Supplements — NCCIH

    Describes what is known about supplements and why safety, quality, and interactions should be considered.

  5. 05
    Evaluation of Natural and Botanical Medicines for Activity Against B. burgdorferi

    Reports laboratory findings for several botanicals; the study was in vitro and does not establish clinical effectiveness.